GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs4272382 | 1 | rs4272382 | chr8:8433488 | TNKS | chr8:9413445-9639855:+ | -0.5 | -6.17 | 1.74E-9 | Response to cytidine analogues (gemcitabine) |
| BLCA | cis | rs4281086 | 1 | rs4281086 | chr8:10352308 | PINX1 | chr8:10622884-10697299:- | -0.22 | -4.17 | 3.84E-5 | Obesity-related traits |
| BLCA | cis | rs4281086 | 1 | rs4281086 | chr8:10352308 | TNKS | chr8:9413445-9639855:+ | -0.24 | -4.83 | 1.97E-6 | Obesity-related traits |
| BLCA | cis | rs2273 | 1 | rs4282209 | chr4:76919536 | NAAA | chr4:76831809-76862166:- | -0.37 | -6.05 | 3.38E-9 | Longevity |
| BLCA | cis | rs9457247 | 1 | rs429083 | chr6:167383972 | RNASET2 | chr6:167343008-167412795:- | -0.23 | -4.95 | 1.14E-6 | Crohn's disease |
| BLCA | cis | rs4294134 | 1 | rs4294134 | chr7:135293128 | PL-5283 | chr7:135347221-135378160:+ | 0.6 | 8.26 | 2.34E-15 | Paget's disease |
| BLCA | cis | rs2149423 | 1 | rs4297570 | chr13:36755179 | SOHLH2 | chr13:36742347-36871992:- | -0.27 | -4.59 | 5.89E-6 | Glucose homeostasis traits |
| BLCA | cis | rs9457247 | 1 | rs430097 | chr6:167405073 | RNASET2 | chr6:167343008-167412795:- | -0.25 | -5.15 | 4.08E-7 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs430293 | chr6:167404958 | RNASET2 | chr6:167343008-167412795:- | -0.25 | -5.15 | 4.08E-7 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs430477 | chr6:167389851 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -5.04 | 7.23E-7 | Crohn's disease |
| BLCA | cis | rs10935120 | 1 | rs4309773 | chr3:134277301 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.7 | 1.15E-13 | Height |
| BLCA | cis | rs10935120 | 1 | rs4309773 | chr3:134277301 | CEP63 | chr3:134204575-134293852:+ | 0.23 | 3.93 | 0.000102 | Height |
| BLCA | cis | rs2243480 | 1 | rs431076 | chr7:65600320 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.56 | 6.79E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs431318 | chr7:65511597 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.38 | 1.51E-5 | Diabetic kidney disease |
| BLCA | cis | rs10461617 | 1 | rs43184 | chr5:56141777 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 11.66 | 4.12E-27 | Type 2 diabetes |